North American competitiveness and resilience to geopolitical and climate disruptions increasingly depend on whether the region can co-design and co-locate its digital and manufacturing supply chains, so they reinforce rather than constrain one another. This approach provides a new paradigm and framework, one based on “ring-fencing” supply chains. Alongside efforts to shift factories closer to home and secure physical inputs, it is equally important to create trusted rules and interoperable systems for data, cloud, and digital services that now sit inside every physical product, production infrastructure, and process.